Check it out at http://jcb.rupress.org/content/early/2017/01/01/jcb.201609124
Oguzhan and I focus on MAPK kinase pathways and review recent work showing how the cell exploits both space and time to make better, more accurate decisions. Arguably, this examination has progressed furthest in the context of budding yeast, which we focus on. It is an exciting time as we move beyond knowing the majority of components in particular signal pathways to understanding how the cell uses all the components together in their physiological context to sense incoming signals, process them, and use that information to make crucial decisions. It has been quite some time coming, but finally, I think it is safe to say that the initial promises of systems biology writ large are coming to fruition (although not through any short cuts, but through long, hard empirical work, informed by theory). In any case, I hope you all enjoy it. Happy new year!