A very nice paper just came out in Developmental Cell by Galli and Morgan. The show that the activation of the spindle assembly checkpoint during work development is controlled by the kinetochore-to-cell size ration. Basically, during early development, cells divide without growth to increase the ratio. There are some very nice manipulations in this paper that really help to solidify a long-standing hypothesis (that i've been aware about in the frog literature) about how the spindle checkpoint is activated during development.

AuthorJan Skotheim