This paper describes one way that spatial organization within the cell can be used to provide an entirely new feature for a network motif (in this case bistable switch from mutual inhibition of Cdk and Far1 activities). We expect that compartmentalization is frequently used to create stable protein pools that can be used to enhance cellular memory of past events (in this case exposure to mating pheromone). Read it, it is good.
The third in Andreas series of papers dismantling the interface between the pheromone-induced MAPK pathway and the cell cycle (see also Doncic et al 2011, 2013 also both Mol. Cell).
Amazing work by Andreas, Oguzhan and our collaborators from Estonian and Argentina.